PIRT Calculator

About the PIRT Score Calculator

The PIRT (Prognostic Index for Relapsed/Refractory Mature T-cell and NK-cell Lymphomas) score is a prognostic tool used to stratify patients with relapsed and refractory mature T and NK-cell lymphomas (MTCL and MNKCL) into low-, intermediate-, and high-risk subgroups, with differing survival outcomes. PIRT was developed based on an international retrospective cohort study encompassing data from select cancer centers in Australia, India, Italy, Japan, Saudi Arabia, South Africa, South Korea, Brazil, and the USA.

The tool uses a patient's demographic and clinical history related to their lymphoma to estimate their survival over a defined time interval. Although a patient’s survival may be estimated with high accuracy, these predictions do not allow for personalized forecasting and hence should be interpreted with caution under the supervision of a qualified healthcare professional.

Risk Factors Survey

Please answer the following questions based on results at diagnosis or closest to diagnosis.

Risk Factors	Present
Are you above the age of 60?
Are you Primary Refractory (Yes) or Relapsed (No)?
Are you AITL (Yes) or not AITL (No)?
Is your number of extranodal involvement greater than one?
Is your Ki67 level greater than 40%?
Is your Absolute Lymphocyte Count less than the lower limit of normal?

Your PIRT Score:

Your Detailed Results

Risk Group	PIRT Score	1-Year Predicted Survival Chance	2-Year Predicted Survival Chance	3-Year Predicted Survival Chance
Result 1	Result 2	Result 3	Result 4	Result 5

The Kaplan-Meier curve illustrates the overall survival from the start of second-line treatment for patients with R/R MTCL and MNKCL in our testing cohort. Populations are stratified into low, intermediate, and high risk groups, represented by green, orange, and red lines, respectively. Shaded areas indicate the 95% confidence intervals for each risk group.

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Disclaimers

▸ The PIRT Score Calculator has not undergone prospective validation. Predictive modeling has been conducted using data from selected sites in Australia, India, Italy, Japan, Saudi Arabia, South Africa, South Korea, Brazil and the USA. Therefore, caution should be exercised when interpreting predictions for populations outside these regions.
▸ Predictions generated by the PIRT Score Calculator are not a substitute for the evaluation and judgment of a licensed clinician or qualified healthcare provider. It is simply a tool to aid the clinician in prognosticating outcomes.
▸ While the PIRT Score Calculator may provide insight into a patient’s risk group, it has not been validated for guiding any clinical decisions, or specific treatment adjustments, and hence should not be used for these purposes.
▸ The PIRT Score Calculator is intended for research purposes only and has not been reviewed or approved by the NCCN (National Comprehensive Cancer Network) and United States Food and Drug Administration (FDA) or any other regulatory agency.